A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics
نویسندگان
چکیده
منابع مشابه
A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics.
Despite the success of large-scale genome-wide association studies (GWASs) on complex traits, our understanding of their genetic architecture is far from complete. Jointly modeling multiple traits' genetic profiles has provided insights into the shared genetic basis of many complex traits. However, large-scale inference sets a high bar for both statistical power and biological interpretability....
متن کاملA powerful approach to estimating annotation-stratified genetic covariance using GWAS summary statistics
~150 words) Despite the success of large-scale genome-wide association studies (GWASs) on complex traits, our understanding of their genetic architecture is far from complete. Jointly modeling multiple traits’ genetic profiles has provided insights into the shared genetic basis of many complex traits. However, large-scale inference sets a high bar for both statistical power and interpretability...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2017
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2017.11.001